ARUK 2021 | The impact of using human stem cells in dementia research

Bryan Ng, PhD Student, University of Oxford, Oxford, UK, discusses the impact of his work on tau-deficient human neurons presented at the Alzheimer’s Research UK (ARUK) Conference 2021. Tau protein aggregation is a major pathological cause of several types of dementia, such as Alzheimer’s disease (AD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and progressive supranuclear palsy (PSP). The use of tau-deficient human neurons derived from stem cells can have an impact on disease modeling and drug development for all these types of dementia. The use of high-throughput analysis and the generation of more consistent disease models are discussed in the video.