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AD/PD 2022 | Protective effect of synaptic stimulation in Alzheimer’s and Parkinson’s disease models

Synaptic activity modulates homeostasis of tau and amyloid-β secretion, and the loss of synapses is a hallmark of Alzheimer’s disease pathology, correlating with cognitive decline. Davide Tampellini, PhD, U1195 INSERM Institute Baulieu, Paris, France, outlines a study showing the protective effect of synaptic stimulation via deep brain stimulation. Following neuron activation, lysosomal activity is increased, degrading pathological tau oligomers. Current research investigates the signaling and cellular mechanisms responsible for this outcome. This interview took place at the AD/PD™ 2022 Conference in Barcelona, Spain.