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AAN 2023 | PMN310 anti-amyloid antibody preserves learning and memory in animal models

PMN310 is a humanized monoclonal antibody which targets a conformational epitope present on misfolded amyloid-beta (Aβ). Johanne Kaplan, PhD, ProMIS™ Neurosciences, Inc., Cambridge, MA, discusses the in vivo data gathered as part of the preclinical development of this investigational antibody. Two animal models were used to interrogate the protective capabilities of PMN310: APP/L transgenic mice and wildtype mice injected intracerebroventricularly with Aβ oligomers. Introduction of toxic oligomers was shown to inhibit short-term memory formation, resulting in an inability to distinguish new from familiar objects. However, when this group was treated with PMN310, memory formation was protected. In the APP/L model, systemic administration of PMN310 preserved memory and learning in the water maze task. This interview took place during the AAN 2023 Annual Meeting in Boston, MA.

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Dr Kaplan is an employee of ProMIS Neurosciences.