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AAIC 2023 | Later-life antidepressant use and dementia risk

Depression in later life is known to be associated with dementia risk, as well as being a common early symptom of the disease. It remains unclear if depression is part of the dementia prodrome or if it is a risk factor. Prior research has explored the impact of depression on Alzheimer’s disease (AD) markers over time, revealing a connection between depression scores in older adults and AD risk biomarker levels. To expand on this, Jaime Ramos Cejudo, PhD, New York University Grossman School of Medicine, New York, NY, conducted a study utilizing electronic health records (EHRs) to investigate if exposure to antidepressants could reduce dementia risk, accounting for various factors, but found no overall association. However, when analyzing by sex, a significant effect emerged in females. This intriguing finding warrants further investigation and validation. This interview took place at the Alzheimer’s Association International Conference® (AAIC) 2023 in Amsterdam, Netherlands.

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