Johannes Levin, MD, Ludwig-Maximilians-Universität München, Munich, Germany, discusses major unanswered questions concerning pathological mechanisms underlying neurodegenerative processes. Working therapies that address the molecular processes are the primary tools necessary to help prove the hypotheses on neurodegeneration; they would help change the disease course and thus provide insight into the pathological mechanisms. Prof. Levin describes prion disease as the most informative for understanding neurodegenerative diseases; the link between propagation and disease is very clear. As there is an abundance of common, specific features like pathological protein aggregates between neurodegenerative diseases – it demonstrates a potential target for therapy, which could provide a wholesome understanding of how these mechanisms work together. This interview was conducted during the 2022 World Congress on Controversies in Neurology (CONy) meeting.