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AAN 2026 | Deep learning-enhanced EEG preprocessing for early Alzheimer’s disease detection

Nardin Samuel, MD, PhD, University of Toronto, Toronto, Canada, discusses the current limitations of EEG for early Alzheimer’s disease (AD) detection, including data acquisition and quality issues, and highlights how deep learning approaches can address these limitations. Dr Samuel discusses a study that builds on previous work demonstrating the potential of AI-based analytics to differentiate between patients with AD and controls using publicly available EEG data. This interview took place at the 78th American Academy of Neurology (AAN) Annual Meeting in Chicago, IL.

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Transcript

So currently for EEG, there are many limitations to its widespread implementation, ranging from data acquisition and access, appropriate training of technicians in order to do this type of data acquisition. And in addition to that, once we have data, actually generating good quality outputs from that data, particularly related to denoising and so data science approaches are necessary in terms of being able to distill signal from noise and then from there utilize that for downstream classification...

So currently for EEG, there are many limitations to its widespread implementation, ranging from data acquisition and access, appropriate training of technicians in order to do this type of data acquisition. And in addition to that, once we have data, actually generating good quality outputs from that data, particularly related to denoising and so data science approaches are necessary in terms of being able to distill signal from noise and then from there utilize that for downstream classification. This study builds on our recently published work in the Journal of Alzheimer’s Disease where we published an EEG study demonstrating that we can apply AI-based pre-processing and post-processing analytics to be able to utilize publicly available EEG data to differentiate between patients with Alzheimer’s disease relative to controls. And this study now sought to build on that to see if we can improve on our pre-processing using deep learning approaches. Again, as mentioned, particularly with application of denoising in order to be able to remove artifacts that in many cases require manual removal or rejection. And from there, that level of data pre-processing enhancement can in turn improve our classification using traditional unsupervised and supervised machine learning models.

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Disclosures

Dr. Samuel has received personal compensation for serving as an employee of Cove Neurosciences Inc..