Educational content on VJDementia is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

AD/PD 2026 | Sleep-based interventions being explored to preserve brain health and delay the progression of AD

Arsenio Paez, DPhil, PhD, Canadian Sleep Society & Concordia University, Montreal, Canada, discusses sleep-based interventions currently being explored to preserve brain health and delay the progression of Alzheimer’s disease (AD). Dr Paez highlights the potential of closed-loop acoustic stimulation and lifestyle modifications, such as exercise, to improve sleep and preserve cognition in individuals at risk of cognitive decline. This interview took place at the AD/PD™ 2026 International Conference on Alzheimer’s and Parkinson’s Diseases in Copenhagen, Denmark.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

Oh, absolutely. And we have studies going on now where people can wear a headband at home and they’re receiving pink noise. It’s not a noise that you necessarily hear, but their brain is being stimulated. These little sound pulses are trying to stimulate those particular sleep physiology markers that we studied to try and see if by doing that, we can actually improve that sleep activity so that they preserve their cognition, so that it may influence their biomarkers...

Oh, absolutely. And we have studies going on now where people can wear a headband at home and they’re receiving pink noise. It’s not a noise that you necessarily hear, but their brain is being stimulated. These little sound pulses are trying to stimulate those particular sleep physiology markers that we studied to try and see if by doing that, we can actually improve that sleep activity so that they preserve their cognition, so that it may influence their biomarkers. So that’s one. It’s called closed-loop acoustic stimulation. It’s something we’re studying in Montreal and with our partners in Spain, but also even something like exercise. Believe it or not, we never think of this. The lifestyle things are so important. It’s more than just about biomarkers and pharmaceuticals. Exercise, we know, improves sleep, especially with people with Alzheimer’s. We’ve shown that in our own work. Exercise improves cognition. It improves mood. Exercise also modifies that sleep physiology. So even something like having older adults at risk of decline or who are declining, exercise really influences that sleep physiology, and that might be another way of really preserving their brain health. So we can do it with these devices, we can do it just by lifestyle modifications, even having people exposed to more enriching experiences. So I think the future really is going to be these multimodal combinations. It could be with pharmaceuticals, but we really need the lifestyle, the multimodal things. And that is where sleep comes in beautifully as well.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...