Genetics

Alzheimer’s disease genetic risk factors by APOE4 status and sex

Genetic risk scores and neuroimaging changes in the FINGER trial

Impact of age, sex, and race on the association between APOE and Alzheimer’s disease

How do genetic scores impact the value of lifestyle interventions?

APOEε4 drives tau accumulation through Aβ-dependent and Aβ-independent pathways

Alzheimer’s disease functional genomics with iPSCs

Impact of APOE4 on cellular function in astrocytes and microglia

Overcoming the limitations of iPSC models

Unraveling the role of microglia in neurodegenerative diseases

Unleashing the potential of microglia as a therapeutic target

The effect of APOE4 on neurovascular coupling

APOEε4 drives Aβ-dependent formation of tau tangles

APOEε4 triggers early microglial activation in Alzheimer’s disease

Investigating TDP-43 pathology with cryptic exons

TDP-43 aggregation drives loss of UNC13A, a risk gene for ALS & FTD

de novo proteins generated from cryptic exon translation in ALS & FTD