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AAIC 2021 | Investigating differences in selective neuronal vulnerability in typical and atypical AD

Lea Grinberg, MD, PhD, Weill Institute for Neurosciences and Memory and Aging Center, University of California, San Francisco, CA, discusses ongoing research aiming to improve our understanding of atypical Alzheimer’s disease (AD) syndromes and how they differ from typical Alzheimer’s cases at a molecular level. Dr Grinberg talks on the need for quantitative mapping of pathological differences in atypical and typical cases, as well as investigations into selective neuronal vulnerability. Dr Grinberg’s team have begun to look into the differences in neuronal vulnerability in typical and atypical AD using single nuclei RNA sequencing. This interview took place during the Alzheimer’s Association International Conference (AAIC) 2021.